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Exosome Therapy for Hair Restoration? - Dr. Explains



Written by

Dr. Asi Peretz
The information is current and up-to-date in
accordance with the latest medical research.



What are exosomes? Exosomes are small vesicles that are released by cells and play a crucial role in intercellular communication. They contain a variety of biomolecules, including proteins, lipids, and nucleic acids, which are used to transfer information between cells. In recent years, exosomes have gained attention for their potential use in hair restoration, as they have been shown to stimulate hair growth in some studies.


Exosomes for Hair Loss

The hair growth process, known as the hair cycle, is controlled by various factors, including hormones, genetics, and environmental factors. During the anagen phase, the active growth phase of the hair cycle, stem cells in the hair follicle are activated and begin to divide, leading to the production of new hair cells. The hair then enters the catagen phase, a transitional phase, before entering the telogen phase, the resting phase. At the end of the telogen phase, the hair falls out, and the cycle begins again.

Exosomes have been shown to promote the anagen phase of the hair cycle, leading to increased hair growth.


In a study published in the Journal of Dermatology, researchers treated human scalp tissue with exosomes derived from human mesenchymal stem cells. The exosomes were found to increase the expression of growth factors, such as VEGF and FGF-7, which are involved in the regulation of hair growth. The researchers also observed an increase in the number of hair follicles in the treated tissue (Yoo et al., 2014).


In addition to promoting hair growth, exosomes have also been shown to have anti-inflammatory effects, which can be beneficial for the treatment of hair loss conditions such as alopecia. In a study published in the Journal of Clinical and Aesthetic Dermatology, researchers treated mice with exosomes derived from human adipose-derived stem cells. The exosomes were found to reduce inflammation and promote hair growth in the mice (Kim et al., 2015).


Exosomes have also been shown to have a positive effect on hair growth in clinical trials. In a randomized, double-blind, placebo-controlled clinical trial, patients with androgenetic alopecia (AGA) were treated with exosomes derived from human adipose-derived stem cells. The exosomes were found to significantly increase hair density and thickness in the treated patients, compared to the placebo group (Lee et al., 2017).


Other studies have also demonstrated the potential of exosomes for the treatment of hair loss. In a study published in the Journal of Dermatology, exosomes derived from human placental stem cells were found to stimulate hair growth and improve hair density in mice with alopecia (Yoo et al., 2015). In another study published in the Journal of Cosmetic Dermatology, exosomes derived from human umbilical cord-derived mesenchymal stem cells were found to increase hair density and thickness in a mouse model of AGA (Kim et al., 2016).


In addition to their potential for the treatment of hair loss, exosomes have also been investigated for their potential use in other dermatological conditions. In a study published in the Journal of Dermatological Science, exosomes derived from human placental stem cells were found to reduce inflammation and improve wound healing in a mouse model of atopic dermatitis (Choi et al., 2016). In another study published in the Journal of Dermatological Science, exosomes derived from human mesenchymal stem cells were found to reduce inflammation and improve skin barrier function in a mouse model of allergic contact dermatitis (Park et al., 2017).



Final thoughts...

Overall, exosomes have demonstrated promising potential for the treatment of hair loss and other dermatological conditions. While further research is needed to fully understand the mechanisms behind their effects and to determine the optimal methods of administration, exosomes show great promise as a potential therapy for a variety of dermatological conditions. Further studies are needed to determine the long-term safety and effectiveness of exosomes in the treatment of hair loss and other dermatological conditions, but their potential as a therapeutic option is exciting and warrants further investigation.


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